Abstract Background The cause of systemic lupus erythematosus is not completely clear so far. but the prevalence of systemic lupus erythematosus is significantly increased in people with additional X chromosomes. Case presentation We report a 17-year-old Chinese female patient with systemic lupus erythematosus complicated with trisomy X. accompanied by lupus nephritis. https://jalyttlers.shop/product-category/black-console/